5-HT1A AND D-2 RECEPTOR AFFINITY OF O-METHOXYPHENYLPIPERAZINE DERIVATIVES WITH TERMINAL BENZAMIDE FRAGMENT ON N-4 ALKYL CHAIN .2.

Authors
PERRONE R BERARDI F LEOPOLDO M TORTORELLA V LOGRANO MD DANIELE E GOVONI S
Citation
R. Perrone et al., 5-HT1A AND D-2 RECEPTOR AFFINITY OF O-METHOXYPHENYLPIPERAZINE DERIVATIVES WITH TERMINAL BENZAMIDE FRAGMENT ON N-4 ALKYL CHAIN .2., Il Farmaco, 50(7-8), 1995, pp. 505-510
Citations number
19
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
50
Issue
7-8
Year of publication
1995
Pages
505 - 510
Database
ISI
SICI code
0014-827X(1995)50:7-8<505:5ADRAO>2.0.ZU;2-5
Abstract
The synthesis of some o-methoxyphenylpiperazines with a benzamide moie ty on N-4 alkyl chain was accomplished and their affinity for dopamine and serotonin receptor subtypes was assayed by in vitro receptor bind ing. The results show that several derivatives had a good affinity bot h on D-2 and 5-HT1A receptors, the IC(50)s ranging from 10(-7) to 10(- 8) M.