Percutaneous endoscopic gastrostomy (PEG) has become a widely used met
hod for nutritional support, particularly in patients with advanced he
ad and neck carcinomas. Since the method is easy and widely establishe
d it is necessary to assess possible complications, even rare ones. In
this paper we report on two patients with vaccination metastasis foll
owing PEG insertion. Both patients had advanced squamous cell carcinom
a of the head and neck or the upper esophagus. In three patients previ
ous bougienage was performed, because of considerable stenosis of the
pharynx and/or esophagus. Fast-growing metastases were found at the si
te of PEG insertion. with and without involvement of the gastric wall.
In neither case was abdominal wall metastasis the cause of death, The
re is a small but definite risk of tumor seeding into the abdominal wa
ll after PEG insertion for obstructive malignant tumors. The clinical
impact of this finding, however, is still undefined and needs further
investigation.