MAPPING A GENE FOR ADULT-ONSET PRIMARY OPEN-ANGLE GLAUCOMA TO CHROMOSOME 3Q

Glaucoma is the third-leading cause of blindness in the world, affecti ng >13.5 million people. Adult-onset primary open-angle glaucoma (POAG ) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal domin ant trait. Twelve affected family members were identified from 44 at-r isk individuals. The disease-causing gene was mapped to chromosome 3q2 1-24, with analysis of recombinant haplotypes suggesting a total inclu sion region of 11.1 cM between markers D3S3637 and D3S1744. This is th e first report of mapping of an adult-onset POAG gene to chromosome 3q , gene symbol GLC1C.