HEMOSTATIC VARIABLES IN ARTERIAL-HYPERTENSION

In 22 untreated patients with uncomplicated essential hypertension and in 10 normotensive subjects the plasma levels of thrombomodulin (TM), beta-thromboglobulin (mu-TG), D-dimer (DD), tissue-type plasminogen a ctivator (t-PA) and plasminogen activator-inhibitor (PAI-1) were evalu ated. The observed values show no significant difference in plasma TM, plasma and urine beta-TG concentration and plasma DD among hypertensi ve patients and controls. On the other hand, the levels of t-PA and PA I-1 in hypertensive patients were significantly higher than the values detected in normotensive control subjects. These data seem to indicat e that, at initial stages of essential hypertension, the t-PA and PAI- 1 levels increase.