EFFECT OF MATERNAL ROTAVIRUS IMMUNIZATION ON MILK AND SERUM ANTIBODY-TITERS

Citation
Lk. Pickering et al., EFFECT OF MATERNAL ROTAVIRUS IMMUNIZATION ON MILK AND SERUM ANTIBODY-TITERS, The Journal of infectious diseases, 172(3), 1995, pp. 723-728
Citations number
70
Categorie Soggetti
Infectious Diseases
ISSN journal
00221899
Volume
172
Issue
3
Year of publication
1995
Pages
723 - 728
Database
ISI
SICI code
0022-1899(1995)172:3<723:EOMRIO>2.0.ZU;2-2
Abstract
This prospective study evaluated human milk and serum antirotavirus an tibody concentrations following maternal rotavirus immunization, Postp artum women (33) were randomized into 3 groups and received a single o ral dose of rhesus rotavirus monovalent reassortant vaccine (10(4) pfu ), tetravalent vaccine (10(4) pfu), or placebo. Milk (secretory [s] Ig A) and serum (IgA and IgG) specimens were tested for antirotavirus iso type-specific antibody. Sera also were tested for G1- to G4-specific a ntibody, Prevaccine milk and serum isotype-specific antibody concentra tions were not significantly different in the 3 groups. Postvaccine sI gA log titers were significantly greater in the 2 vaccine groups than the placebo group (P = .002), Mean log(10) titers at 1 week were 2.1 ( 95% confidence interval [CI], 2.0-2.3) in the 2 vaccine groups and 1.7 (95% CI, 1.5-1.9) in the placebo group. Milk titers did not differ be tween vaccine groups. There was no difference in reactogenicity betwee n groups. The significantly higher milk concentrations of antibody to rotavirus in postpartum women who received rotavirus immunization pers isted for 4 months.