Lk. Pickering et al., EFFECT OF MATERNAL ROTAVIRUS IMMUNIZATION ON MILK AND SERUM ANTIBODY-TITERS, The Journal of infectious diseases, 172(3), 1995, pp. 723-728
This prospective study evaluated human milk and serum antirotavirus an
tibody concentrations following maternal rotavirus immunization, Postp
artum women (33) were randomized into 3 groups and received a single o
ral dose of rhesus rotavirus monovalent reassortant vaccine (10(4) pfu
), tetravalent vaccine (10(4) pfu), or placebo. Milk (secretory [s] Ig
A) and serum (IgA and IgG) specimens were tested for antirotavirus iso
type-specific antibody. Sera also were tested for G1- to G4-specific a
ntibody, Prevaccine milk and serum isotype-specific antibody concentra
tions were not significantly different in the 3 groups. Postvaccine sI
gA log titers were significantly greater in the 2 vaccine groups than
the placebo group (P = .002), Mean log(10) titers at 1 week were 2.1 (
95% confidence interval [CI], 2.0-2.3) in the 2 vaccine groups and 1.7
(95% CI, 1.5-1.9) in the placebo group. Milk titers did not differ be
tween vaccine groups. There was no difference in reactogenicity betwee
n groups. The significantly higher milk concentrations of antibody to
rotavirus in postpartum women who received rotavirus immunization pers
isted for 4 months.