COMPARISON OF EFFICACY OF HIGH-DOSE PURE FOLLICLE-STIMULATING-HORMONEVERSUS HUMAN MENOPAUSAL GONADOTROPINS FOR IN-VITRO FERTILIZATION

The advent of recombinant DNA technology will soon produce for the mar ket a product that has pure follicle-stimulating hormone (pFSH) but no luteinizing hormone. A prospective randomized study was performed to see if pFSH (Metrodin(R)) was able to stimulate the same in vitro fert ilization parameters as human menopausal gonadotropin when preceded by gonadotropin suppression by leuprolide acetate. The results showed si milar parameters between the two drugs, i.e., number of oocytes, numbe r of embryos, endometrial thickness at time of human chorionic gonadot ropin, fertilization rates and pregnancy rates in a protocol purposely designed to stimulate as many follicles as safely as possible because of a shared oocyte and successful cryopreservation program.