A. Gimelfarb et R. Lande, MARKER-ASSISTED SELECTION AND MARKER-QTL ASSOCIATIONS IN HYBRID POPULATIONS, Theoretical and Applied Genetics, 91(3), 1995, pp. 522-528
A detailed analysis is presented of the relationship between genetic m
arkers and quantitative trait loci (QTLs) in the process of marker-ass
isted selection (MAS). We simulated MAS employing a multiple linear re
gression to chose from among all of the markers in the genome those to
be utilized by selection and to estimate their associated effects on
the trait. The simulations demonstrate that, even when such selection
is quite effective, the markers utilized by selection are not necessar
ily the most tightly linked to the QTLs controling the trait. Moreover
, the additive effects associated with the markers estimated by the re
gression may not accurately reflect the contributions to the trait by
the most tightly linked QTLs.