ADENOSINE DIALDEHYDE BLOCKS THE DISAPPEARANCE OF 2 NERVE GROWTH FACTOR-INDUCED INSOLUBLE PROTEINS

Authors
VANDENBURG JY MCFADDEN PN
Citation
Jy. Vandenburg et Pn. Mcfadden, ADENOSINE DIALDEHYDE BLOCKS THE DISAPPEARANCE OF 2 NERVE GROWTH FACTOR-INDUCED INSOLUBLE PROTEINS, Journal of protein chemistry, 14(5), 1995, pp. 291-297
Citations number
34
Categorie Soggetti
Biology
Journal title
Journal of protein chemistry → ACNP
ISSN journal
02778033
Volume
14
Issue
5
Year of publication
1995
Pages
291 - 297
Database
ISI
SICI code
0277-8033(1995)14:5<291:ADBTDO>2.0.ZU;2-2
Abstract
Two nonionic-detergent-insoluble proteins are induced early in the ner ve growth factor (NGF)-induced neuronal differentiation of PC12 cells. The pools of these two proteins then disappear from the insoluble fra ction after a few days of continued exposure of the cells to NGF. The methylation-inhibiting drug adenosine dialdehyde blocks the disappeara nce of these insoluble proteins, implicating a methylation-dependent s tep in the pathway that regulates the fate of these proteins.