EFFECT OF DIRECTLY ULTRAVIOLET-IRRADIATED ALLOGRAFTS OF FETAL PANCREAS IN EXPERIMENTAL DIABETIC DOGS

The proliferative responses of UV-irradiated islets from fetal pancrea s decreased to 53.8+/-4.7% (mean+/-SEM) compared to that of UV-irradia ted islets by allogeneic mixed islet-cell lymphocyte culture. In 5 pan createctomized dogs, UV irradiated fetal dog pancreas was transplanted either into omentum pouches or the spleen without immunosuppressive a gents. The diabetic status (daily insulin requirement for hyperglycemi a, decrease in body weight, urine glucose) improved in dogs after allo -transplantation. The survival time after total pancreatectomy was sig nificantly longer in allografted dogs than those treated only with dai ly insulin injections.