EFFECTS OF HYPOVOLEMIC SHOCK AND REPERFUSION ON LIVER BLOOD-FLOW IN THE DOG

Liver blood how was investigated in hypovolemic shock using a modified right heart bypass technique which can obtain accurate portal blood f low. Findings were similar to those previously reported: hepatic blood flow accounted for 34% of cardiac output in this study; 76% of hepati c blood how was delivered from the portal vein and 24% from the hepati c artery. Hypovolemic shock markedly decreased total liver blood how b y a reduction in portal venous blood how. The findings of this study p rovide evidence that mesenteric blood flow is a peripheral circulation circuit where blood flow is restricted during reduced circulatory vol ume. Development of a hepatic arterial buffer response during hypovole mic shock was confirmed by an increased ratio of hepatic arterial flow to cardiac output. Reduced total hepatic blood flow during hypovolemi c shock returned to control flow by an increase in hepatic arterial fl ow after reperfusion. The results of this study demonstrate that compe nsated reactions for maintaining liver blood flow mainly due to the he patic arterial buffer response were functioned both during hypovolemic shock and after elimination of shock.