EFFECT OF PLATELET-ACTIVATING-FACTOR ANTAGONIST (TCV-309) ON LUNG INJURY IN DOGS WITH EXPERIMENTALLY ENDOTOXIN-INDUCED SHOCK

The effect of TCV-309, a newly developed platelet activating factor (P AF) antagonist, on the wet/dry weight ratio of the lung (index of pulm onary edema) and the pulmonary surface activity (index of pulmonary co mpliance) was evaluated in comparison with that of CV-3988 (PAF-antago nist). Administration of TCV-309 (1 mg/kg) or CV-3988 (10 mg/kg) signi ficantly reduced the wet/dry weight ratio which was increased by endot oxin administration (3 mg/kg). It also augmented the pulmonary surface activity. Administration of either TCV-309 or CV-3988 alleviated the histologic lesions caused by endotoxic shock. These results suggest th at lung injury during endotoxic shock can be controlled by TCV-309 as by CV-3988.