CHIRAL CAPILLARY HPLC AND HPLC-MS - NEW APPLICATIONS OF CHEMICALLY BONDED BETA-CYCLODEXTRIN AS STATIONARY-PHASE

Authors
CABRERA K JUNG M KEMPTER C SCHURIG V
Citation
K. Cabrera et al., CHIRAL CAPILLARY HPLC AND HPLC-MS - NEW APPLICATIONS OF CHEMICALLY BONDED BETA-CYCLODEXTRIN AS STATIONARY-PHASE, Fresenius' journal of analytical chemistry, 352(7-8), 1995, pp. 676-678
Citations number
23
Categorie Soggetti
Chemistry Analytical
Journal title
Fresenius' journal of analytical chemistry → ACNP
ISSN journal
09370633
Volume
352
Issue
7-8
Year of publication
1995
Pages
676 - 678
Database
ISI
SICI code
0937-0633(1995)352:7-8<676:CCHAH->2.0.ZU;2-G
Abstract
Chemically bonded beta-cyclodextrin (ChiraDex(R)) has been packed into 0.25 mm i.d. capillaries and used for the enantiomer separation of se veral pharmaceuticals by capillary HPLC with UV and electrospray ioniz ation (ESI) MS detection. While having several advantages over convent ional HPLC, capillary HPLC yielded comparable results, e.g. with respe ct to resolution and sensitivity. The good compatibility to ESI-MS was demonstrated.