H. Caulier et al., EFFECT OF CALCIUM-PHOSPHATE (CA-P) COATINGS ON TRABECULAR BONE RESPONSE - A HISTOLOGICAL STUDY, Journal of biomedical materials research, 29(9), 1995, pp. 1061-1069
The trabecular bone response to noncoated and fluorapatite (FA), hydro
xyapatite (HA), and hydroxyapatite heat-treated (HAHT) plasma-sprayed
coated implants was investigated in a goat animal model. Forty-eight c
ylindrical implants were inserted into the trabecular bone of the late
ral and medial femoral condyles of twelve goats according to a split p
lot design. After an implantation period of twelve weeks, the bone-imp
lant interface was evaluated histologically. Quantitative histomorphom
etrical measurements demonstrated a significant difference in bone con
tact between implants inserted in the lateral and medial condyles. In
addition, a significant difference in bone apposition was observed bet
ween the coated and the uncoated implants. Finally, all Ca-P coatings
showed reduction in coating thickness. Measurements revealed that FA a
nd HAHT showed less reduction in coating thickness than HA coating. De
spite the coating reduction, the bone remained in close contact with t
he implant surface. (C) 1995 John Wiley & Sons, Inc.