LINKAGE ANALYSES OF CHROMOSOME-18 MARKERS DO NOT IDENTIFY A MAJOR SUSCEPTIBILITY LOCUS FOR BIPOLAR AFFECTIVE-DISORDER IN THE OLD-ORDER AMISH

Authors
PAULS DL OTT J PAUL SM ALLEN CR FANN CSJ CARULLI JP FALLS KM BOUTHILLIER CA GRAVIUS TC KEITH TP EGELAND JA GINNS EI
Citation
Dl. Pauls et al., LINKAGE ANALYSES OF CHROMOSOME-18 MARKERS DO NOT IDENTIFY A MAJOR SUSCEPTIBILITY LOCUS FOR BIPOLAR AFFECTIVE-DISORDER IN THE OLD-ORDER AMISH, American journal of human genetics, 57(3), 1995, pp. 636-643
Citations number
39
Categorie Soggetti
Genetics & Heredity
Journal title
American journal of human genetics → ACNP
ISSN journal
00029297
Volume
57
Issue
3
Year of publication
1995
Pages
636 - 643
Database
ISI
SICI code
0002-9297(1995)57:3<636:LAOCMD>2.0.ZU;2-M
Abstract
Previously reported linkage of bipolar affective disorder to DNA marke rs in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D 18S21, D18S53, D18S44, and D18S40) were examined in three kindreds con taining 31 bipolar I (BP I) individuals. Although linkage findings wer e replicated in the one previously studied Amish pedigree containing f our BP I individuals, linkage to this region was excluded in the large r sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this pop ulation.