CANDIDATE GENE STUDIES IN PEDIGREES WITH MATURITY-ONSET DIABETES OF THE YOUNG NOT LINKED WITH GLUCOKINASE

Maturity-onset diabetes of the young (MODY) is a form of non-insulin-d ependent diabetes mellitus characterised by an early age of onset and an autosomal dominant mode of inheritance. Only a proportion of cases are due to mutations in the glucokinase gene. We have studied five Cau casian MODY families, including the first MODY family to be described, with five candidate genes implicated in regulation of insulin secreti on. The affected subjects showed more marked hyperglycaemia than that found in subjects with glucokinase mutations. We assessed polymorphic markers close to the genes for glucokinase, hexokinase II, adenosine d eaminase, pituitary adenylate cyclase-activating polypeptide receptor, and glucagon-like peptide-1 receptor. Linkage analysis with diabetes gave cumulative log of the odds (LOD) scores of less than -3, implying that mutations in these genes are unlikely to provide a major genetic contribution to this form of MODY.