Objective: To review the scientific evidence supporting an association
between unemployment and adverse health outcomes and to assess the ev
idence on the basis of the epidemiologic criteria for causation. Data
sources: MEDLINE was searched for all relevant articles with the use o
f the MeSH terms ''unemployment,'' ''employment,'' ''job loss,'' ''eco
nomy'' and a range of mortality and morbidity outcomes. A secondary se
arch was conducted for references from the primary search articles, re
view articles or published commentaries. Data and definitions of unemp
loyment were drawn from Statistics Canada publications. Study selectio
n: Selection focused on articles published in the 1980s and 1990s. Eng
lish-language reports of aggregate-level research (involving an entire
population), such as time-series analyses, and studies of individual
subjects, such as cross-sectional, case-control or cohort studies, wer
e reviewed. In total, the authors reviewed 46 articles that described
original studies. Data extraction: Information was sought on the assoc
iation (if any) between unemployment and health outcomes such as morta
lity rates, specific causes of death, incidence of physical and mental
disorders and the use of health care services. Information was extrac
ted on the nature of the association (positive or negative), measures
of association (relative risk, odds ratio or standardized mortality ra
tio), and the direction of causation (whether unemployment caused ill
health or vice versa). Data synthesis: Most aggregate-level studies re
ported a positive association between national unemployment rates and
rates of overall mortality and mortality due to cardiovascular disease
and suicide. However, the relation between unemployment rates and mot
or-vehicle fatality rates may be inverse. Large, census-based cohort s
tudies showed higher rates of overall mortality, death due to cardiova
scular disease and suicide among unemployed men and women than among e
ither employed people or the general population. Workers laid off beca
use of factory closure have reported more symptoms and illnesses than
employed people; some of these reports have been validated objectively
. Unemployed people may be more likely than employed people to visit p
hysicians, take medications or be admitted to general hospitals. A pos
sible association between unemployment and rates of admission to psych
iatric hospitals is complicated by other institutional and environment
al factors. Conclusions: Evaluated on an epidemiologic basis, the evid
ence suggests a strong, positive association between unemployment and
many adverse health outcomes. Whether unemployment causes these advers
e outcomes is less straightforward however, because there are likely m
any mediating and confounding factors, which may be social, economic o
r clinical. Many authors have suggested mechanisms of causation, but f
urther research is needed to test these hypotheses.