PROGRESS OF UNRELATED BONE-MARROW DONOR SEARCH AT THE UNIVERSITY-HOSPITAL-OF-ESSEN (1991-1994)

The development of unrelated bone marrow donor search (UMDS) was analy zed in a retrospective single-center study covering the period from 19 91 to 1994., The data files of the 285 enrolled UMDS patients were eva luated for the patients' underlying disease, HLA phenotype frequency, year of search start, UMDS duration/outcome, and the origin of identif ied donors. Within 3 months after UMDS start, a donor was found in 5%, 10%,19%, and 49% of the searches started in 1991 (n = 57), 1992 (n = 7 3), 1993 (n = 77), and 1994 (n = 78, until September), respectively, T he total UMDS success rate increased from 53% (1991 group) to 67% (199 4 group), with 5% and 54%, respectively, of the accepted donors being supplied by German registries. Thus, the current UMDS procedure provid es a suitable donor for the majority of the patients lacking a related donor, and the majority of the donors are now facilitated by national donor centers.