EFFECT OF TEMPERATURE ON A MULTICOMPONENT ULTRAVIOLET SPECTROMETRIC DETERMINATION AND THE DEVELOPMENT OF A TEMPERATURE-INDEPENDENT ASSAY PROCEDURE

Authors
BOURNE R BURGESS C
Citation
R. Bourne et C. Burgess, EFFECT OF TEMPERATURE ON A MULTICOMPONENT ULTRAVIOLET SPECTROMETRIC DETERMINATION AND THE DEVELOPMENT OF A TEMPERATURE-INDEPENDENT ASSAY PROCEDURE, Analyst, 120(8), 1995, pp. 2075-2080
Citations number
7
Categorie Soggetti
Chemistry Analytical
Journal title
Analyst → ACNP
ISSN journal
00032654
Volume
120
Issue
8
Year of publication
1995
Pages
2075 - 2080
Database
ISI
SICI code
0003-2654(1995)120:8<2075:EOTOAM>2.0.ZU;2-F
Abstract
The effect of temperature variations on the spectrometric analysis of a two-component pharmaceutical preparation, ranitidine injection, has been investigated. Assay temperature coefficients of up to 0.8% degree s C-1 were obtained. A temperature-compensating approach, whereby a tw o-component solution can be analysed at any (unknown) temperature agai nst reference standard solutions measured at other unknown temperature s, has been developed and validated.