FLUCONAZOLE-RESISTANT SYSTEMIC CANDIDIASI S IN A 17-DAY-OLD NEWBORN

In a 17-day-old newborn with systemic candidiasis fluconazole proved i neffective to prevent the progression of the disease. Fluconazole had been recommended as a treatment alternative to amphotericin B in syste mic candida infections. In our case, progression of the infection and a threatening lung failure made necessary a switch to amphotericin-B a nd 5-flucytosine. Despite high serum trough-levels and fluconazole-sen sitivity of the candida albicans species, the infection could not be c ontrolled. In this case report the efficacy of fluconazole in dissemin ated candida infection is discussed.