Insect pests are a major cause of damage to the world's commercially i
mportant agricultural crops, Current strategies aimed at reducing crop
losses rely primarily on chemical pesticides. Alternatively transgeni
c crops with intrinsic pest resistance offer a promising alternative a
nd continue to be developed. The first generation of insect-resistant
transgenic plants are based on insecticidal proteins from Bacillus thu
ringiensis (Bt). A second generation of insect-resistant plants under
development include both Bt and non-Bt proteins with novel modes of ac
tion and different spectra of activity against insect pests.