ELECTRICALLY-INDUCED NGF PRODUCTION BY ASTROGLIAL CELLS

Authors
KOYAMA S HARUYAMA T KOBATAKE E AIZAWA M
Citation
S. Koyama et al., ELECTRICALLY-INDUCED NGF PRODUCTION BY ASTROGLIAL CELLS, Nature biotechnology, 15(2), 1997, pp. 164-166
Citations number
15
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Nature biotechnology → ACNP
ISSN journal
10870156
Volume
15
Issue
2
Year of publication
1997
Pages
164 - 166
Database
ISI
SICI code
1087-0156(1997)15:2<164:ENPBAC>2.0.ZU;2-V
Abstract
A controlled culture system has been developed to induce nerve growth factor (NGF) production in astroglial cells that are cultured on an el ectrode surface. The electrode potential is alternatively modulated at an amplitude of 300 mV and a frequency of 10 Hz. The electric stimula tion triggers NGF production and secretion. The mechanism of the elect rically induced NGF production is discussed in association with protei n kinase C (PKC) activation.