EVALUATION OF PROTECTIVE EFFECTS OF PROSTAGLANDIN E(1) ON ISCHEMIC LIVER-DAMAGE WITH IN-VIVO P-31-MR SPECTROSCOPY

The cytoprotective effect of prostaglandins (pc) was evaluated by in v ivo P-31 MR spectroscopy. Twenty rabbits were divided into two groups; the control group given physiological saline, and the PG group given prostaglandin E(1) (0.5 mu g/kg/min), Each solution was infused for 8 min, after which complete hepatic ischemia was induced for 20 min, fol lowed by reperfusion for 40 min. During ischemia, beta-ATP decreased t o 23.6% and 42.3%, phosphomonoester increased to 260% and 200% of thei r initial values in the control and the PG groups, respectively, Inorg anic phosphate also increased. After reperfusion, beta-ATP recovered t o 65.2% and 96.5%, phosphomonoester to 130% and 110%, inorganic phosph ate to 140% and 120% in the control and PG groups, respectively. The c hanges during ischemia were significantly smaller and the recoveries d uring reperfusion were more complete in the PG group. These results ma y confirm the cytoprotective effect of prostaglandins by in vivo P-31- MR spectroscopy.