INTERACTIONS BETWEEN SODIUM TAURODEOXYCHOLATE MICELLES AND CRYPTANDS

The influence of the synthetic macrocycle 4,7,13,16,21,24-hexaoxa-1,10 -diazabicyclo [8.8.8]hexacosane on the intermolecular interactions of sodium taurodeoxycholate aqueous solutions has been investigated by cr yoscopic, conductometric, and surface tension methods. The results sho w that the cryptand causes an appreciable shift of the critical micell ar concentrations, toward the lower bile salt concentration. In additi on, the complexing agent strongly affects the conductance and enhances the surfactant properties of the taurodeoxycholate. These features ha ve been interpreted in terms of hydrophobic interactions between compl exed counterion and amphipatic anion.