NUCLEOPHILIC-SUBSTITUTION OF HALOGEN IN 4-HALOGENATED DERIVATIVES OF GLUTAMIC-ACID .2. STRUCTURAL EFFECTS OF ARYLAMINE AS NUCLEOPHILE

Authors
KRASNOV VP KOROLEVA MA EVSTIGNEEVA NG NIZOVA IA
Citation
Vp. Krasnov et al., NUCLEOPHILIC-SUBSTITUTION OF HALOGEN IN 4-HALOGENATED DERIVATIVES OF GLUTAMIC-ACID .2. STRUCTURAL EFFECTS OF ARYLAMINE AS NUCLEOPHILE, Russian chemical bulletin, 44(4), 1995, pp. 635-638
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Russian chemical bulletin → ACNP
ISSN journal
10665285
Volume
44
Issue
4
Year of publication
1995
Pages
635 - 638
Database
ISI
SICI code
1066-5285(1995)44:4<635:NOHI4D>2.0.ZU;2-Q
Abstract
Kinetics of nucleophilic substitution of halogen in diastereomeric dim ethyl 4-bromo- and 4-iodoglutamates with ortho-, meta-, and para-subst ituted anilines was studied by HPLC. The threo-diastereomers of the ha logenated derivatives react 3-5 times faster than the erythro ones. Th e structure of the transition state is discussed.