SYNTHESIS OF SUBSTITUTED NICOTINAMIDES FROM ENAMINES DERIVED FROM N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL

Authors
ABUSHANAB FA ALY FM WAKEFIELD BJ
Citation
Fa. Abushanab et al., SYNTHESIS OF SUBSTITUTED NICOTINAMIDES FROM ENAMINES DERIVED FROM N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, Synthesis, (8), 1995, pp. 923-925
Citations number
3
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1995
Pages
923 - 925
Database
ISI
SICI code
0039-7881(1995):8<923:SOSNFE>2.0.ZU;2-J
Abstract
Reactions of 1,3-dicarbonyl compounds with N,N-dimethylformamide dimet hyl acetal followed by malonamide in the presence of sodium hydride gi ve 5,6-disubstituted 1,2-dihydro-2-oxopyridine-3-carboxamides 3 a-c, w hereas reactions of the intermediate enamines with cyanothioacetamide or cyanoacetamide in the presence of piperidine give 4,5-disubstituted 1,2-dihydro-2-thioxopyridine-3-carboxamides 6 a-c and 1,2-dihydro-2-o xopyridine-3-carboxamides 6 d-b.