A SYNTHESIS OF (3R-ASTERISK,4R-ASTERISK)-LUFFARIOLIDE-E VIA 1,2-METALATE REARRANGEMENT

Authors
HAREAUVITTINI G KOCIENSKI P REID G
Citation
G. Hareauvittini et al., A SYNTHESIS OF (3R-ASTERISK,4R-ASTERISK)-LUFFARIOLIDE-E VIA 1,2-METALATE REARRANGEMENT, Synthesis, (8), 1995, pp. 1007-1013
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
8
Year of publication
1995
Pages
1007 - 1013
Database
ISI
SICI code
0039-7881(1995):8<1007:ASO(V1>2.0.ZU;2-Z
Abstract
A key step in the synthesis of (3R,4R*)-Luffariolide E is a 1,2-metal late rearrangement of a higher order cuprate to generate a trisubstitu ted double bond stereoselectively. The synthetic product is a diastere oisomer of the natural marine cytotoxic agent (3S,4R)-Luffariolide E.