MYOPATHIC INVOLVEMENT IN 2 CASES OF HALLERVORDEN-SPATZ DISEASE

Muscle biopsy was performed in two patients with Hallervorden-Spatz di sease and increased serum creatine kinase levels, Morphological analys is showed myopathic signs such as subsarcolemmal accumulation of myelo id structures, dense bodies and debris, endomysial macrophage activati on, focal necrosis and fiber splitting, We emphasize the finding of mu scle involvement in Hallervorden-Spatz disease, like in other forms of neuroacanthocytosis.