FAMILIAL HYPERTROPHIC CARDIOMYOPATHY WITH WOLFF-PARKINSON-WHITE SYNDROME MAPS TO A LOCUS ON CHROMOSOME 7Q3

We have mapped a disease locus for Wolff-Parkinson-White syndrome (WPW ) and familial hypertrophic cardiomyopathy (PHC) segregating in a larg e kindred to chromosome 7 band q3, Although WPW syndrome and FHC have been observed in members of the same family in prior studies, the rela tionship between these two diseases has remained enigmatic. A large fa mily with 25 surviving individuals who are affected by one or both of these conditions was studied, The disease locus is closely linked to l oci D7S688, D7S505, and D7S483 (maximum two point LOD score at D7S505 was 7.80 at theta = 0), While four different FHC loci have been descri bed this is the first locus that can be mutated to cause both WPW and/ or FHC.