A SIMPLE GENETIC-BASIS FOR A COMPLEX PSYCHOLOGICAL TRAIT IN LABORATORY MICE

Psychological traits are commonly inferred from covariation in sets of behavioral measures that otherwise appear to have little in common. E motionality in mice is such a trait, defined here by covariation in ac tivity and defecation in a novel environment and emergence into the op en arms of an elevated plus maze. Behavioral and quantitative trait an alyses were conducted on four measures obtained from 879 mice from an F-2 intercross. Three loci, on murine chromosomes 1, 12, and 15, were mapped that influence emotionality. This trait, inferred from studies of strain, sex, and individual differences in rodents, may be related to human susceptibility to anxiety or neuroticism.