MOLECULAR MODELING OF ACYCLIC ATACTIC OLIGONUCLEOTIDES IN A-DOUBLE-HELIX

Authors
MERLE Y
Citation
Y. Merle, MOLECULAR MODELING OF ACYCLIC ATACTIC OLIGONUCLEOTIDES IN A-DOUBLE-HELIX, Journal of trace and microprobe techniques, 13(3), 1995, pp. 339-340
Citations number
4
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of trace and microprobe techniques → ACNP
ISSN journal
07334680
Volume
13
Issue
3
Year of publication
1995
Pages
339 - 340
Database
ISI
SICI code
0733-4680(1995)13:3<339:MMOAAO>2.0.ZU;2-H
Abstract
Molecular modeling of an acyclic oligonucleotide analogue, associated with its complementary natural oligonucleotide, shows that the atactic configuration does not hinder the formation of an A double helix. Thi s can explain the sharp transition at 24 degrees C of the double stran d molecule (GlyA)(12),(dT)(12) prepared elsewhere.