CEREBROSPINAL NEURON-SPECIFIC ENOLASE, S-100 AND MYELIN BASIC-PROTEININ NEUROLOGICAL DISORDERS

In this study levels of neuron-specific enolase (NSE), S-100 protein ( S-100) and myelin basic protein (MBP) in cerebrospinal fluid (CSF) of children and adults with distinct neurological disorders were examined . A previous study from our department demonstrated age related refere nce values for these brain-specific proteins in CSF. The median concen tration level of the 3 proteins in 17 different neurological disease g roups versus the reference group was compared. Significantly higher MB P values were observed in patients with multiple sclerosis (MS), cereb rovascular accident (CVA), metabolic disorder and infection. Furthermo re, significantly higher values were demonstrated for S-100 in CVA and for NSE in metabolic diseases. In CVA, the NSE and S-100 values were significantly related with MBP values, whereas in MS the NSE and S-100 were not related with MBP values.