RISK-FACTORS FOR POSTSTROKE DEPRESSION

An unselected cohort of 285 stroke patients, median age 69 years, were studied for correlation between potential risk factors and the 1-year incidence of post-stroke depression (PSD). The following factors corr elated significantly with PSD: a history of previous stroke, a history of previous depression, female gender, living alone and social distre ss prestroke. Further, social inactivity, decrease in social activity, pathological crying and intellectual impairment at 1 month but not fu nctional outcome correlated to PSD. A multivariate regression analysis showed that intellectual impairment explained 42% of variance of mood score. Major depression was unrelated to lesion location. We conclude that etiology to PSD is a complex mixture of prestroke personal and s ocial factors, and stroke induced social, emotional and intellectual h andicap.