A NOVEL SYNTHESIS OF ISOINDOLINE AND ISOQUINOLINE USING CHROMIUM CARBENE COMPLEX

Authors
MORI M KURIYAMA K OCHIFUJI N WATANUKI S
Citation
M. Mori et al., A NOVEL SYNTHESIS OF ISOINDOLINE AND ISOQUINOLINE USING CHROMIUM CARBENE COMPLEX, Chemistry Letters, (8), 1995, pp. 615-616
Citations number
8
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
8
Year of publication
1995
Pages
615 - 616
Database
ISI
SICI code
0366-7022(1995):8<615:ANSOIA>2.0.ZU;2-Z
Abstract
The reaction of diyne 1 which has nitrogen in a tether with chromium c arbene complex 2 afforded isoindoline 4 in good yield. In this reactio n, the two carbene carbons (carbene carbon of chromium carbene complex and carbon monoxide) reacted with the two alkynes, respectively, to f orm an aromatic ring, that is, [2+2+1+1] cocyclization. Using this pro cedure, isoquinoline derivatives, 6a, 7a, and 9a, were synthesized.