Citation
A. Jegorov et al., SPECTROSCOPIC AND STRUCTURAL STUDY OF FLOBUFEN, Journal of fluorine chemistry, 73(2), 1995, pp. 213-219
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear
Journal title
ISSN journal
00221139
Volume
73
Issue
2
Year of publication
1995
Pages
213 - 219
Database
ISI
SICI code
0022-1139(1995)73:2<213:SASSOF>2.0.ZU;2-6
Abstract
Flobufen, ',4'-difluorobiphenyl-4-y1)-2-methyl-4-oxobutanoic acid, and
its 3-methyl isomer have been obtained by the Friedel-Crafts reaction
of 2,4-difluorobiphenyl with itaconic or citraconic anhydride, respec
tively, followed by hydrogenation of the products. The structures of b
oth compounds have been elucidated by mass spectrometry and H-1, C-13
and F-19 NMR spectroscopy. The structure of flobufen has been confirme
d by a single-crystal X-ray study.