Lg. Menon et al., INHIBITION OF LUNG METASTASIS IN MICE INDUCED BY B16F10 MELANOMA-CELLS BY POLYPHENOLIC COMPOUNDS, Cancer letters, 95(1-2), 1995, pp. 221-225
Several polyphenolic compounds were tested for the inhibition of lung
metastasis induced by B16F10 melanoma cells in mice. Oral administrati
on of polyphenols such as curcumin and catechin at concentrations of 2
00 nmol/kg body weight were found to inhibit the lung metastasis maxim
ally as seen by the reduction in the number of lung tumor nodules (80%
). Other polyphenols which inhibited the lung tumor nodule formation w
ere rutin (71.2%), epicatechin (61%), naringin (27.2%) and naringenin
(26.1%). The polyphenols which did not inhibit lung tumor nodule forma
tion were quercetin, morin and ellagic acid. Consequent to the inhibit
ion of the lung tumor nodules, the life span of animals treated with p
olyphenols was also found to be increased. Curcumin (143.85%), catechi
n (80.81%) and rutin (63.59%) had maximal increase in life span. The r
esults indicate a possible use of these compounds in arresting the met
astatic growth of tumor cells.