SYNTHESIS OF 2-AMINOQUINAZOLINES FROM ORTHO-FLUOROKETONES

The reactions of ten ortho-fluoroketones with guanidine carbonate in N ,N-dimethylacetamide were investigated as a new synthetic approach to 2-amino-4-alkyl- and 2-amino-4-arylquinazolines. The yields obtained r anged from low to moderate and were highly dependent upon the nature o f the substituents on the reactant. Eight new quinazolines were elabor ated in this study.