SERUM LEVELS OF INTERLEUKIN-4 AND SOLUBLE CD23 IN CHILDREN WITH ALLERGIC DISORDERS

Citation
Y. Ohshima et al., SERUM LEVELS OF INTERLEUKIN-4 AND SOLUBLE CD23 IN CHILDREN WITH ALLERGIC DISORDERS, European journal of pediatrics, 154(9), 1995, pp. 723-728
Citations number
28
Categorie Soggetti
Pediatrics
ISSN journal
03406199
Volume
154
Issue
9
Year of publication
1995
Pages
723 - 728
Database
ISI
SICI code
0340-6199(1995)154:9<723:SLOIAS>2.0.ZU;2-P
Abstract
In order to clarify the clinical significance of serum interleukin 4 ( IL-4) levels, we measured serum IL-4 concentrations in allergic and no n-allergic children using a highly sensitive sandwich ELISA. The limit of detection of the assay was 0.15 pg/ml in serum samples. Serum IL-4 was detected in 96.3% (53/55) of non-allergic controls, in 99.9% (183 /197) of allergic children, in 70% (7/10) of cord blood samples and in 86.7% (26/30) of neonates. The IL-4 levels in sera from non-allergic controls were relatively constant during the ages examined and all sam ples were under 1.5 pg/ml. In allergic children, the serum levels of I L-4 were significantly elevated, particularly at age 13 similar to 24 months. The serum levels of IL-4 did not differ in children with diffe rent clinical manifestations of allergy, such as bronchial asthma, and atopic dermatitis. The serum level of soluble CD23 (sCD23) showed an age-dependent change in allergic and nonallergic children and was sign ificantly higher in allergic than in non-allergic infants aged 7 to 12 months, but not in other age groups. There was no significant correla tion among serum levels of IL-4, sCD23 and IgE. Conclusion It is sugge sted that the measurement of serum IL-4 and sCD23 is helpful in the ex amination of allergic patients in infancy and early childhood, but nei ther the serum level of IL-4 nor sCD23 directly reflects in vivo IgE p roduction.