THE INHIBITION OF FCT ON THE BIOSYNTHESIS OF DNA IN EHRLICH ASCITES CANCER-CELLS

Authors
GUO ML YANG P ZHAO CG YANG BS YANG WP
Citation
Ml. Guo et al., THE INHIBITION OF FCT ON THE BIOSYNTHESIS OF DNA IN EHRLICH ASCITES CANCER-CELLS, Gaodeng xuexiao huaxue xuebao, 16(8), 1995, pp. 1177-1179
Citations number
5
Categorie Soggetti
Chemistry
Journal title
Gaodeng xuexiao huaxue xuebao → ACNP
ISSN journal
02510790
Volume
16
Issue
8
Year of publication
1995
Pages
1177 - 1179
Database
ISI
SICI code
0251-0790(1995)16:8<1177:TIOFOT>2.0.ZU;2-3
Abstract
The effect of FcT[Ferricenium trichloroacetate, bis(trichloroacetic ac id) solvate] on the biosynthesis of DNA in EAC cells in vitro was repo rted in this paper. The experimental results show that FcT, similar to another anticancer agent titanocene dichloride(TDC), caused a remarka ble depression of DNA synthesis activities, and the half-inhibition co ncentration for FcT is about 1.0X10(-4) mol/L. The irreversible and lo ng-lasting inhibition manner of FcT on DNA biosynthesis indicated that the DNA template was injured by FcT. Meanwhile, the fluorescent quenc hing of DNA-EB complex by FcT revealed that the DNA duplex might be da maged by FcT.