SCAVENGING OF FREE-RADICALS AND INHIBITION OF LIPID-PEROXIDATION BY 3-PHENYLSYDNONE

The antioxidant properties of 3-phenylsydnone were studied in various models in-vitro. 3-Phenylsydnone scavenged the stable free radical, 1, 1-diphenyl-2-picrylhydrazyl, and inhibited the degradation of deoxyrib ose mediated by hydroxyl radicals, although, to a lesser extent than t rolox, a water soluble analogue of vitamin E. Many antioxidants posses s pro-oxidant properties due to their ability to reduce ferric ions; h owever, 3-phenylsydnone was free from pro-oxidant properties, and also inhibited the lipid peroxidation induced by iron, in rat brain homoge nates.