We describe the problems of clinical assessment of subclavian catheter
placement whose course was noted to be along the left lateral border
of the heart, suggesting malposition. After the catheter's position in
a persistent left superior vena cava was confirmed by blood gas analy
sis, lateral chest X-ray film, and venography, the catheter was used t
o provide total parenteral nutrition without complications, The evalua
tion and workup of seeming malposition of central venous catheters and
the embryologic development of a left-sided vena cava are discussed.