Two cases are reported demonstrating that mediastinal scintigraphy for
hyperparathyroidism should be routinely performed along with scintigr
aphy of the neck region. Because of the relative cost-benefit ratio, c
onsideration should also be given to performing the procedure before t
he initial surgery. For the most accurate diagnosis and favorable outc
ome, our cases suggest that scintigraphic physiologic results should b
e correlated with anatomic results of conventional radiography.