The modern era of blood vessel imaging began in 1929 when Forssmann in
jected himself with contrast medium through a large bore catheter.(1)
Although recognised to be a hazardous procedure the diagnostic ability
of angiography was quickly appreciated and a whole new field of neuro
surgery rapidly emerged. Dott in Edinburgh wrapped a cerebral aneurysm
in 1932(2) and Eastcott in London performed the first carotid endarte
rectomy in 1954.(3) While angiographic techniques have continued to im
prove, so has the appreciation of the risks; when the benefits of trea
tment are minimal, such as in patients with low grade carotid stenosis
, the risks of angiography can outweigh its benefits. This has led to
the search for less invasive modalities to image the blood vessels. Th
is article reviews these new methods, particularly Doppler ultrasonogr
aphy (DUS), magnetic resonance angiography (MRA), and CT. It also disc
usses what is the role for angiography other than its accepted use for
vascular lesions in the head such as aneurysms and arteriovenous malf
ormations. The remaining role of angiography in imaging the carotid bi
furcation is the current subject of heated debate. The intensity of th
is debate was recently increased by the North American Symptomatic Car
otid Endarterectomy Trial (NASCET)(4) and the European Carotid Surgery
Trial (ECST)(5) both of which showed that 70% stenosis, when measured
from an angiogram, could select a group of patients that benefited fr
om carotid surgery but that non-invasive measurement, when performed a
s in NASCET, did not satisfactorily select these patients.(6)