TREATMENT OF MULTIFOCAL MOTOR NEUROPATHY WITH HIGH-DOSE INTRAVENOUS IMMUNOGLOBULINS - A DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY

The effect of high dose intravenous immunoglobulin (IVIg) treatment wa s studied in six patients with multifocal motor neuropathy (MMN). All patients responded to treatment (0.4 g/kg for five consecutive days) i n an open trial. The effect of IVIg treatment was confirmed for each p atient in a single patient, double blind, placebo controlled trial. Fo ur patients received two IVIg treatments and two placebo treatments, a nd two patients received one IVIg and one placebo treatment in a rando mised order. Five out of six patients responded to IVIg but not to pla cebo. One patient responded to IVIg in the same manner as to placebo t reatment. Thus IVIg treatment can lead to improvement of muscle streng th in patients with MMN.