We have compared the effect of peritonsillar infiltration with tenoxic
am 5 mg and placebo on postoperative pain after tonsillectomy. Fifty p
atients undergoing bilateral elective tonsillectomy under general anae
sthesia were allocated randomly to receive peritonsillar infiltration
with tenoxicam 5 mg in 8 ml of normal saline (4 ml per tonsil) or norm
al saline only, before tracheal extubation. Median time to first reque
st for morphine (30 min in each group, P = 0.83), cumulative morphine
requirements from 0 to 2 h after surgery (two and one doses, P = 0.50)
, and from 2 to 24 h after surgery (one dose in each group, P = 0.17)
were similar. There were no significant differences between groups in
VAS scores at rest or when drinking 100 ml of water at any time. The p
ower of detecting a reduction in VAS scores of 20 mm was 90% at the 5%
significance level.