EFFECTS OF INTRAOPERATIVE N-ACETYLCYSTEINE IN ORTHOTOPIC LIVER-TRANSPLANTATION

N-acetylcysteine (NAC) is an antioxidant agent which has been shown to benefit patients with fulminant hepatic failure. We have examined its effect in patients with chronic liver disease undergoing orthotopic l iver transplantation by giving NAC during operation. In a prospective, randomized, double-blind, placebo-controlled study of 50 patients, NA C appeared to induce mild vasodilatation, improve oxygen delivery and consumption, and reduce base deficit, but data interpretation was diff icult. There were no significant effects on mortality, morbidity or po stoperative graft function.