Organ transplantation has become the treatment of choice for patients
with end-stage organ failure and has led to progressive increases in t
he size of waiting lists over the past decade. Unfortunately, from 199
0 to 1994, the number of organ donors remained stable while the number
of organs transplanted from these donors increased by only 10 %. In v
iew of the severity of the current organ shortage, elderly individuals
are increasingly being accepted as organ donors. The graft survival r
ate with kidneys from donors older than 55 years is 5 % lower than tha
t with kidneys from younger donors at 1 year and 9 % lower at 3 years
post-transplantation. Graft survival is also significantly lower with
organs from donors who die from cerebrovascular accidents than it is w
ith organs from donors whose cause of death is cerebral trauma. The nu
mber of patients waiting for a nonrenal donor organ has increased rapi
dly in the past 5 years, and-an increasing number of donor kidneys are
now being provided by multiorgan donors. The favorable graft survival
rate with multiorgan donor kidneys, which is significantly better tha
n that obtained with single organ donor kidneys, confirms their suit a
bility for renal transplantation.