EUROPEAN GENE-MAPPING PROJECT (EUROGEM) - BREAKPOINT PANELS FOR HUMAN-CHROMOSOMES BASED ON THE CEPH REFERENCE FAMILIES

Meiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9 , 10, 13, 14, 15, 17; 18, 20 and X were constructed from genotypes fro m the CEPH reference families. Each recombinant chromosome included ha s a breakpoint well-supported with reference to defined quantitative c riteria. The panels were constructed at both a low-resolution, useful for a first-pass localization, and high-resolution, for a more precise placement. The availability of such panels will reduce the number of genotyping experiments necessary to order new polymorphisms with respe ct to existing genetic markers. This paper shows only a representative sample of the breakpoints detected. The complete data are available o n the World Wide Web (URL ttp://www.ienet.uk/axp/hgr/eurogem/HTML/data .html) or by anonymous ftp (ftp.gene.ucl.ac.uk in /pub/eurogen/maps/br eakpoints).