DECREASED SERUM APOLIPOPROTEIN B-100 AND A-I CONCENTRATIONS IN COWS WITH KETOSIS AND LEFT DISPLACEMENT OF THE ABOMASUM

Objective-To assess the relevance of hepatic lipidosis (fatty liver) i n the development of ketosis and left displacement of the abomasum (LD A). Sample Population-Sera from 22 healthy cows in early lactation, 21 cows with ketosis, and 19 cows with LDA, and serum and liver specimen s from 35 slaughtered cows with or without fatty liver, ketosis, and/o r LDA. Procedure-Apolipoprotein B-100 and A-l concentrations were meas ured in sera of healthy farm cows and of farm cows with ketosis and LD A. Serum apolipoprotein concentration, together with liver triglycerid e content, also were surveyed in a subset of slaughtered cows. Results -Compared with those in healthy cows or controls, apolipoprotein B-100 and A-l concentrations were decreased in cows with ketosis and LDA. C onclusions-Decreases in apolipoprotein B-100 and A-l concentrations in cows with ketosis and LDA indicate that the 2 disorders may be intima tely associated with fatty liver. Clinical Relevance-Monitoring of the apolipoprotein B-100 and A-l concentrations during the stages of nonl actation and early lactation is helpful for detecting cows susceptible to ketosis and IDA.