ROLE OF 55- AND 75-KDA TNF RECEPTORS IN THE POTENTIATION OF FC-MEDIATED PHAGOCYTOSIS IN HUMAN NEUTROPHILS

Authors
DELLABIANCA V DUSI S NADALINI KA DONINI M ROSSI F
Citation
V. Dellabianca et al., ROLE OF 55- AND 75-KDA TNF RECEPTORS IN THE POTENTIATION OF FC-MEDIATED PHAGOCYTOSIS IN HUMAN NEUTROPHILS, Biochemical and biophysical research communications, 214(1), 1995, pp. 44-50
Citations number
24
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
214
Issue
1
Year of publication
1995
Pages
44 - 50
Database
ISI
SICI code
0006-291X(1995)214:1<44:RO5A7T>2.0.ZU;2-7
Abstract
Human neutrophils respond with an increased phagocytosis when exposed to TNF. Two types of TNF receptors have been identified, namely 55 kDa (TR55) and 75 kDa (TR75). We addressed the problem of the role of the se receptors in the priming effect of TNF. By using monoclonal antibod ies (MoAbs) directed either against TR55 or TR75, we have shown that 1 ) only TR55 is the signaling receptor for the potentiation of Fc-media ted phagocytosis and upregulation of beta 2-integrin CD11b/CD18; 2) TR 75 may control the function of TR55 by regulating the binding of TNF t o the signaling receptor. (C) 1995 Academic Press, Inc.