CYTOTOXIC ALKALOIDS FROM THE FLATWORM PROSTHECERAEUS-VILLATUS AND ITSTUNICATE PREY CLAVELINA-LEPADIFORMIS

Authors
KUBANEK J WILLIAMS DE DESILVA ED ALLEN T ANDERSEN RJ
Citation
J. Kubanek et al., CYTOTOXIC ALKALOIDS FROM THE FLATWORM PROSTHECERAEUS-VILLATUS AND ITSTUNICATE PREY CLAVELINA-LEPADIFORMIS, Tetrahedron letters, 36(35), 1995, pp. 6189-6192
Citations number
5
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
35
Year of publication
1995
Pages
6189 - 6192
Database
ISI
SICI code
0040-4039(1995)36:35<6189:CAFTFP>2.0.ZU;2-S
Abstract
Four novel alkaloids, lepadins B (2) and C (3) and villatamines A (4) and B (5), have been isolated from the predatory flatworm Prosthecerae us villatus and its tunicate prey Clavelina lepadiformis. Lepadins A ( 1) and B (2) and villatamine B (5) exhibit significant in vitro cytoto xicity against human cancer cell lines.